Optic nerve development

Across TCGA patient cohorts, RNA activity of the Optic nerve development pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NAV2, SLC66A3, and GREM2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Optic nerve development activity versus NAV2 in LUAD (Pearson r = -0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NAV2 →	+0.902	+0.424	<.001	<.001	3	5
UCEC	SLC66A3 →	-0.620	-0.340	<.001	.001	3	4
OV	GREM2 →	+0.499	+0.658	.001	.003	3	4
GBM	ADAMTSL2 →	+0.688	+0.471	<.001	<.001	3	4
OV	ARHGEF26-AS1 →	-0.148	-0.747	.006	.004	3	4
LUAD	FNDC5 →	+0.584	+0.227	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021554 vs NAV2 — LUAD

Explore this scatter interactively →