Optic nerve development

Across TCGA cell cohorts, RNA activity of the Optic nerve development pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNA2, TGIF2-RAB5IF, and KCNJ3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KCNA2 grouped by Optic nerve development-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	KCNA2 →	-0.266	-1.198	<.001	<.001	2	6
BLOOD_Leukemia	TGIF2-RAB5IF →	-0.341	-1.871	.009	.003	3	4
BLOOD_Leukemia	KCNJ3 →	-0.240	-1.423	.002	<.001	3	4
BLOOD_Myeloma	PRMT9 →	+0.363	+2.316	.004	<.001	3	4
BLOOD_Leukemia	IFNB1 →	+0.193	+1.359	.001	<.001	3	4
BLOOD_Myeloma	PPP1R14B →	-0.248	-1.470	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KCNA2 by Optic nerve development activity — PANCREAS

Explore this box plot interactively →