Optic nerve development

Across TCGA cell cohorts, RNA activity of the Optic nerve development pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TEAD4, ASB8, and REEP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TEAD4 grouped by Optic nerve development-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TEAD4 →	-1.015	-1.491	<.001	<.001	3	5
LIVER	ASB8 →	+0.790	+1.323	<.001	.003	3	4
LUNG_NSCLC_LUAD	REEP4 →	+0.444	+0.673	.001	<.001	3	4
BLOOD_Leukemia	NFATC4 →	-1.948	-0.847	.007	.006	3	4
SKIN	CERS4 →	-1.858	-0.859	<.001	.001	3	3
STOMACH	HERC6 →	+1.430	+0.992	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TEAD4 by Optic nerve development activity — OESOPHAGUS

Explore this box plot interactively →