Rhombomere development

pathway activity — cross-omics
GO:0021546Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Rhombomere development pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FTH1P15, CCDC34, and HSPA8, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADFTH1P15 →+0.725+0.270.004<.00133
GBMCCDC34 →-0.490-0.223.007.00132
GBMHSPA8 →-0.257-0.175.003.00632
GBMSLC10A3 →+0.396+0.181.008.00432
GBMSFXN1 →-0.337-0.190.008.00832
GBMMETTL9 →-0.278-0.206.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration