Cranial nerve development

Across TCGA patient cohorts, RNA activity of the Cranial nerve development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLEC11A, COL12A1, and SFRP2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cranial nerve development activity versus CLEC11A in LSCC (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CLEC11A →	+0.688	+0.051	<.001	<.001	3	7
LSCC	COL12A1 →	+1.367	+0.063	<.001	<.001	3	7
CCRCC	SFRP2 →	+1.241	+0.087	.002	<.001	2	7
LSCC	POSTN →	+1.017	+0.042	<.001	.005	3	6
PDAC	SERPINF1 →	+0.548	+0.037	.001	.003	3	6
LSCC	SULF1 →	+0.967	+0.056	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021545 vs CLEC11A — LSCC

Explore this scatter interactively →