Cranial nerve development

Across TCGA patient cohorts, RNA activity of the Cranial nerve development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRAP2, CRTAM, and MS4A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cranial nerve development activity versus GRAP2 in BRCA (Pearson r = -0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GRAP2 →	-0.495	-0.607	.001	.002	3	4
BRCA	CRTAM →	-0.611	-0.809	.001	<.001	3	4
BRCA	MS4A1 →	-1.144	-0.699	<.001	<.001	3	4
BRCA	HTRA4 →	-0.720	-0.727	<.001	<.001	3	4
UCEC	CCR4 →	-0.574	-0.285	.004	.009	3	4
BRCA	TRGV2 →	-0.535	-0.585	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021545 vs GRAP2 — BRCA

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