Pallium development

Across TCGA patient cohorts, RNA activity of the Pallium development pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BLNK, PSMB10, and SSR3_S105, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pallium development activity versus BLNK in HNSC (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	BLNK →	-0.534	-0.052	<.001	<.001	3	7
LSCC	PSMB10 →	-0.580	-0.036	<.001	<.001	3	7
LSCC	SSR3_S105 →	-0.796	-0.022	<.001	.005	3	6
GBM	CLASP1 →	+0.265	+0.033	<.001	.002	3	6
GBM	EPS8L2_S240 →	-0.805	-0.022	.002	.005	3	6
GBM	FCHSD1 →	-0.293	-0.033	.008	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021543 vs BLNK — HNSC

Explore this scatter interactively →