Pallium development

Across TCGA patient cohorts, RNA activity of the Pallium development pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are P3H3, B4GALNT1, and GPR161, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pallium development activity versus P3H3 in OV (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	P3H3 →	+1.395	+0.620	<.001	.002	3	2
OV	B4GALNT1 →	+0.777	+0.636	<.001	.002	3	2
OV	GPR161 →	+0.813	+0.580	.004	.005	3	2
OV	IGFBP7 →	+1.252	+0.619	<.001	.002	3	2
OV	TUBA1A →	+0.976	+0.620	.001	.002	3	2
OV	RFLNB →	+1.582	+0.630	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021543 vs P3H3 — OV

Explore this scatter interactively →