Pallium development

Across TCGA cell cohorts, RNA activity of the Pallium development pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASMTL, CBFA2T2, and LAP3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ASMTL grouped by Pallium development-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ASMTL →	-0.197	-0.167	.004	.009	3	4
OVARY	CBFA2T2 →	+0.202	+0.205	.007	.001	3	4
BONE	LAP3 →	+0.365	+0.155	.007	.009	3	4
LUNG_SCLC	MEGF10 →	-0.286	-0.263	<.001	.005	3	4
URINARY_TRACT	C1QL2 →	+0.286	+0.207	.002	.006	3	3
SKIN	HBM →	-0.341	-0.151	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ASMTL by Pallium development activity — BREAST

Explore this box plot interactively →