Pallium development

Across TCGA cell cohorts, RNA activity of the Pallium development pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP55, PAFAH1B1, and KIRREL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pallium development activity versus CEP55 in URINARY_TRACT (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CEP55 →	+0.921	+0.159	.003	.001	3	6
OVARY	PAFAH1B1 →	+0.597	+0.143	.006	.007	3	6
LIVER	KIRREL1 →	+3.084	+0.322	.005	.003	3	5
LIVER	SHISA4 →	+2.807	+0.254	<.001	.001	3	5
LARGE_INTESTINE	RSC1A1 →	+0.719	+0.151	.003	.001	3	5
OESOPHAGUS	LRP12 →	+2.812	+0.241	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021543 vs CEP55 — URINARY_TRACT

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