Corpus callosum morphogenesis

Across TCGA patient cohorts, RNA activity of the Corpus callosum morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VSIR, VSIR_S235, and RCSD1_S68, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Corpus callosum morphogenesis activity versus VSIR in UCEC (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VSIR →	-0.417	-0.062	<.001	.002	3	6
UCEC	VSIR_S235 →	-0.461	-0.075	.007	.009	3	5
HNSC	RCSD1_S68 →	-0.433	-0.060	.001	.002	3	5
HNSC	BRD7 →	+0.201	+0.059	<.001	.001	3	4
LSCC	HAT1 →	+0.395	+0.048	.006	.003	3	4
HNSC	HNRNPM →	+0.196	+0.074	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021540 vs VSIR — UCEC

Explore this scatter interactively →