Diencephalon development

Across TCGA patient cohorts, RNA activity of the Diencephalon development pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STAT1, MKI67_S357, and MAP1B_S1819, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Diencephalon development activity versus STAT1 in CCRCC (Pearson r = -0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	STAT1 →	-0.625	-0.037	<.001	.004	3	6
GBM	MKI67_S357 →	-0.726	-0.048	.002	<.001	3	6
GBM	MAP1B_S1819 →	+0.260	+0.040	.003	.003	3	6
HNSC	GBP1 →	-0.713	-0.054	.001	<.001	3	5
CCRCC	RRM2_S20 →	-0.905	-0.063	<.001	<.001	3	5
LSCC	SF3B1 →	-0.220	-0.072	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021536 vs STAT1 — CCRCC

Explore this scatter interactively →