Diencephalon development

Across TCGA cell cohorts, RNA activity of the Diencephalon development pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EXT1, DSE, and TMEM117, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EXT1 grouped by Diencephalon development-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	EXT1 →	-1.731	-1.667	.002	<.001	3	6
BONE	DSE →	-2.137	-1.762	.001	<.001	3	6
LIVER	TMEM117 →	+0.955	+1.336	.009	.001	2	6
LARGE_INTESTINE	RTF2 →	-0.602	-0.733	.001	<.001	3	5
BONE	GSDME →	-2.899	-1.148	<.001	.002	3	5
SOFT_TISSUE	AKT3 →	-3.111	-1.585	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EXT1 by Diencephalon development activity — SOFT_TISSUE

Explore this box plot interactively →