Cell differentiation in hindbrain

Across TCGA patient cohorts, RNA activity of the Cell differentiation in hindbrain pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRIA4, PSMB3P1, and C15orf40, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell differentiation in hindbrain activity versus GRIA4 in CCRCC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	GRIA4 →	+1.834	+0.481	<.001	.001	3	3
CCRCC	PSMB3P1 →	-0.364	-0.411	<.001	.004	3	3
UCEC	C15orf40 →	+0.279	+0.382	.007	.006	3	3
UCEC	SERHL2 →	+0.511	+0.328	.001	.007	3	3
UCEC	RNU6-1280P →	+0.796	+0.358	.001	.001	3	3
OV	MYF6 →	-0.112	-0.820	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021533 vs GRIA4 — CCRCC

Explore this scatter interactively →