Cell differentiation in hindbrain

Across TCGA cell cohorts, RNA activity of the Cell differentiation in hindbrain pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UNKL, LHX5, and AGBL3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UNKL grouped by Cell differentiation in hindbrain-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	UNKL →	-0.435	-1.256	<.001	.001	3	7
CNS	LHX5 →	-0.287	-1.153	.001	<.001	3	7
LUNG_NSCLC_LUAD	AGBL3 →	-0.230	-1.115	.001	<.001	2	7
LUNG_NSCLC_LUAD	WNT7A →	-0.183	-0.989	<.001	<.001	3	6
OVARY	GRID2 →	-0.191	-1.078	<.001	<.001	3	6
CNS	PEX1 →	-0.370	-1.093	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UNKL by Cell differentiation in hindbrain activity — CNS

Explore this box plot interactively →