Cell differentiation in hindbrain

Across TCGA cell cohorts, RNA activity of the Cell differentiation in hindbrain pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF207, EXOSC3, and SIAE, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell differentiation in hindbrain activity versus ZNF207 in LUNG_SCLC (Pearson r = -0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ZNF207 →	-0.580	-1.733	<.001	.005	3	1
LUNG_SCLC	EXOSC3 →	-0.645	-1.086	.002	.002	3	1
LUNG_SCLC	SIAE →	+1.968	+1.439	<.001	.009	3	1
LUNG_SCLC	FAM184A →	-1.940	-1.452	.003	.004	3	1
LUNG_SCLC	MRPL3 →	-0.781	-1.084	<.001	.002	3	1
LUNG_SCLC	ASB3 →	-0.756	-1.029	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021533 vs ZNF207 — LUNG_SCLC

Explore this scatter interactively →