Cell differentiation in hindbrain

Across TCGA cell cohorts, RNA activity of the Cell differentiation in hindbrain pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PBDC1, OGDH, and CHCHD3, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell differentiation in hindbrain activity versus PBDC1 in LUNG_SCLC (Pearson r = -0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PBDC1 →	-0.910	-0.759	.009	.005	3	1
LUNG_SCLC	OGDH →	+0.573	+0.716	.004	.009	3	1
LUNG_SCLC	CHCHD3 →	+0.637	+0.960	.006	.007	3	1
LUNG_SCLC	DRG2 →	-1.188	-1.009	.001	.007	3	1
LUNG_SCLC	YWHAE →	-0.793	-0.976	.006	.008	3	1
LUNG_SCLC	LAMTOR3 →	+0.770	+0.829	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021533 vs PBDC1 — LUNG_SCLC

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