Spinal cord motor neuron differentiation

Across TCGA patient cohorts, RNA activity of the Spinal cord motor neuron differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOK3, MACROH2A2, and SAMSN1_S23, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spinal cord motor neuron differentiation activity versus DOK3 in BRCA (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DOK3 →	-0.386	-0.039	<.001	<.001	3	8
LUAD	MACROH2A2 →	+0.263	+0.038	.004	<.001	3	7
LSCC	SAMSN1_S23 →	-0.481	-0.043	.007	.001	3	6
COAD	NAXE →	+0.460	+0.038	<.001	<.001	3	6
BRCA	CASP10 →	-0.531	-0.044	.001	<.001	3	6
COAD	RO60 →	+0.218	+0.033	.004	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021522 vs DOK3 — BRCA

Explore this scatter interactively →