Spinal cord motor neuron differentiation

Across TCGA patient cohorts, RNA activity of the Spinal cord motor neuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BLOC1S1, NEK2, and PEF1-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Spinal cord motor neuron differentiation activity versus BLOC1S1 in CCRCC (Pearson r = -0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	BLOC1S1 →	-0.225	-0.796	<.001	<.001	3	4
LSCC	NEK2 →	-0.611	-0.129	.002	.006	3	4
LSCC	PEF1-AS1 →	+0.413	+0.178	<.001	.002	3	4
COAD	F13A1 →	+1.422	+0.984	<.001	<.001	3	3
COAD	TDO2 →	+0.682	+0.755	.008	.002	3	3
COAD	KCTD15 →	+0.440	+0.490	.005	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021522 vs BLOC1S1 — CCRCC

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