Cell differentiation in spinal cord

Across TCGA patient cohorts, RNA activity of the Cell differentiation in spinal cord pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOK3, HCK, and CASP4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell differentiation in spinal cord activity versus DOK3 in CCRCC (Pearson r = -0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	DOK3 →	-0.499	-0.075	<.001	<.001	3	8
BRCA	HCK →	-0.412	-0.039	<.001	<.001	3	8
LSCC	CASP4 →	-0.440	-0.056	<.001	<.001	3	8
OV	RO60 →	+0.303	+0.039	<.001	.005	3	7
LSCC	SOX6_S411 →	+1.386	+0.069	<.001	<.001	3	7
LSCC	UNC13D →	-0.648	-0.072	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021515 vs DOK3 — CCRCC

Explore this scatter interactively →