Cell differentiation in spinal cord

Across TCGA patient cohorts, RNA activity of the Cell differentiation in spinal cord pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM97, RAD51AP1, and PGAP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell differentiation in spinal cord activity versus TMEM97 in HNSC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TMEM97 →	+0.835	+0.342	.002	.008	3	4
HNSC	RAD51AP1 →	+0.479	+0.288	.007	.003	3	4
LSCC	PGAP1 →	+0.974	+0.777	<.001	<.001	3	4
CCRCC	OTULINL →	-0.423	-0.750	<.001	.002	3	3
GBM	DKC1 →	+0.209	+0.558	.002	.001	2	4
HNSC	RPL35P6 →	+0.497	+0.297	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021515 vs TMEM97 — HNSC

Explore this scatter interactively →