Cell differentiation in spinal cord

Across TCGA cell cohorts, RNA activity of the Cell differentiation in spinal cord pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF3L, ECHS1, and PGAP6, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell differentiation in spinal cord activity versus EIF3L in BLOOD_Leukemia (Pearson r = -0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EIF3L →	-0.803	-1.875	.005	<.001	3	3
STOMACH	ECHS1 →	+1.530	+2.043	.005	.006	3	3
STOMACH	PGAP6 →	+0.983	+2.043	.005	.006	3	3
LARGE_INTESTINE	HKDC1 →	+3.986	+1.425	.006	<.001	3	3
LUNG_SCLC	KCTD9 →	-0.827	-1.728	.002	.001	3	3
BLOOD_Leukemia	EEF1G →	-0.772	-1.895	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0021515 vs EIF3L — BLOOD_Leukemia

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