Hemoglobin metabolic process

Across TCGA patient cohorts, RNA activity of the Hemoglobin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PF4, HBA1, and SLC4A3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hemoglobin metabolic process activity versus PF4 in BRCA (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PF4 →	+0.364	+0.163	.005	.005	3	3
BRCA	HBA1 →	+1.257	+0.203	<.001	.001	3	3
OV	SLC4A3 →	+0.928	+0.291	.001	<.001	3	3
OV	SLC25A5P8 →	-0.456	-0.199	.002	.003	3	3
OV	ASLP1 →	+0.644	+0.206	.003	.009	3	3
HNSC	RNU6-298P →	+0.852	+0.471	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0020027 vs PF4 — BRCA

Explore this scatter interactively →