Translesion synthesis

Across TCGA patient cohorts, RNA activity of the Translesion synthesis pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP128, SMCHD1, and CEP192, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Translesion synthesis activity versus CEP128 in THYM (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	CEP128 →	+1.268	+0.039	<.001	<.001	3	34
UVM	SMCHD1 →	+1.503	+0.057	<.001	<.001	3	34
DLBC	CEP192 →	+1.559	+0.081	<.001	.003	3	34
SARC	CCP110 →	+1.312	+0.057	<.001	<.001	3	34
UVM	TRIM37 →	+0.925	+0.051	<.001	<.001	3	34
KICH	CNOT6 →	+1.179	+0.048	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019985 vs CEP128 — THYM

Explore this scatter interactively →