Axonal transport of mitochondrion

Across TCGA cell cohorts, RNA activity of the Axonal transport of mitochondrion pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPC24, SPATA13, and ABHD13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPC24 grouped by Axonal transport of mitochondrion-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SPC24 →	+0.813	+1.026	.002	<.001	3	5
SOFT_TISSUE	SPATA13 →	-1.701	-1.515	.006	<.001	3	4
LUNG_NSCLC_LUSC	ABHD13 →	-0.412	-1.261	.008	.001	3	4
LUNG_NSCLC_LUSC	MDP1 →	-0.953	-1.563	.001	<.001	3	4
OVARY	SESTD1 →	-1.677	-1.421	.002	<.001	3	4
LIVER	FAM50B →	-1.895	-1.503	.009	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPC24 by Axonal transport of mitochondrion activity — PANCREAS

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