Axonal transport of mitochondrion

Across TCGA cell cohorts, RNA activity of the Axonal transport of mitochondrion pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EXOSC9, RPS2, and FZD5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axonal transport of mitochondrion activity versus EXOSC9 in LARGE_INTESTINE (Pearson r = -0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EXOSC9 →	-0.822	-0.670	.005	.004	3	5
STOMACH	RPS2 →	-0.998	-0.911	.003	.006	3	4
LUNG_SCLC	FZD5 →	+0.945	+0.797	.009	.009	3	4
SKIN	RNPS1 →	-0.379	-0.657	.003	.007	3	4
CNS	TOE1 →	-0.750	-1.259	.007	<.001	3	4
CNS	PNPLA8 →	+0.810	+0.793	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019896 vs EXOSC9 — LARGE_INTESTINE

Explore this scatter interactively →