Antigen processing and presentation of endogenous antigen

Across TCGA patient cohorts, RNA activity of the Antigen processing and presentation of endogenous antigen pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STAT1, STAT1_S532, and TAP1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antigen processing and presentation of endogenous antigen activity versus STAT1 in COAD (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	STAT1 →	+0.657	+0.051	<.001	<.001	3	10
HNSC	STAT1_S532 →	+0.864	+0.068	<.001	<.001	3	10
LSCC	TAP1 →	+0.625	+0.077	<.001	<.001	3	10
UCEC	TAP2 →	+0.733	+0.108	<.001	<.001	3	10
LSCC	TAPBP →	+0.650	+0.074	<.001	<.001	3	10
HNSC	TRIM21 →	+0.481	+0.078	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019883 vs STAT1 — COAD

Explore this scatter interactively →