Antigen processing and presentation of endogenous antigen

Across TCGA patient cohorts, RNA activity of the Antigen processing and presentation of endogenous antigen pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRF1, HCP5, and PSMB9, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antigen processing and presentation of endogenous antigen activity versus IRF1 in BRCA (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IRF1 →	+0.806	+0.220	<.001	<.001	3	10
BRCA	HCP5 →	+0.917	+0.260	<.001	<.001	3	10
OV	PSMB9 →	+1.399	+0.274	<.001	<.001	3	10
OV	BTN3A3 →	+1.032	+0.228	<.001	<.001	3	10
OV	NLRC5 →	+0.970	+0.178	<.001	.002	3	10
HNSC	GBP4 →	+1.214	+0.239	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019883 vs IRF1 — BRCA

Explore this scatter interactively →