Pyrimidine nucleobase biosynthetic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine nucleobase biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LDB3, XPA, and ZBTB22, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleobase biosynthetic process activity versus LDB3 in LUAD (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LDB3 →	-0.299	-0.130	.001	.004	3	5
BRCA	XPA →	-0.424	-0.181	<.001	.002	3	5
BRCA	ZBTB22 →	-0.276	-0.128	.007	.006	3	5
OV	ARHGEF15 →	-0.521	-0.153	.003	.001	3	5
LUAD	PAOX →	-0.195	-0.166	.008	.004	3	4
CCRCC	EHD4-AS1 →	-0.317	-0.093	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019856 vs LDB3 — LUAD

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