Pyrimidine nucleobase biosynthetic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine nucleobase biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACYP2, TUBA1A, and ATP6V1G2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACYP2 grouped by Pyrimidine nucleobase biosynthetic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ACYP2 →	-1.258	-0.225	<.001	.004	3	4
LARGE_INTESTINE	TUBA1A →	-1.752	-0.216	.006	.001	3	4
LUNG_SCLC	ATP6V1G2 →	-1.755	-0.419	.008	.001	3	4
SKIN	CDR2L →	-1.405	-0.219	.001	.004	3	4
BLOOD_Lymphoma	ZNF433 →	-1.454	-0.388	.001	.002	3	4
KIDNEY	PSG9 →	-0.674	-0.204	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACYP2 by Pyrimidine nucleobase biosynthetic process activity — STOMACH

Explore this box plot interactively →