L-ascorbic acid metabolic process

Across TCGA patient cohorts, RNA activity of the L-ascorbic acid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC5, TDP2, and POLR1A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-ascorbic acid metabolic process activity versus RFC5 in LSCC (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RFC5 →	+0.314	+0.073	<.001	<.001	3	6
LSCC	TDP2 →	+0.472	+0.066	<.001	.001	3	5
LSCC	POLR1A →	+0.250	+0.054	.001	.003	3	5
LUAD	SPP1_S234 →	+1.022	+0.066	.008	.004	3	5
LSCC	GCLC →	+1.133	+0.102	<.001	<.001	3	5
COAD	REPS2 →	-0.346	-0.051	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019852 vs RFC5 — LSCC

Explore this scatter interactively →