Cytolysis

Across TCGA cell cohorts, RNA activity of the Cytolysis pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNTTIP1, LOXL2, and ZNF461, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNTTIP1 grouped by Cytolysis-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DNTTIP1 →	+0.728	+1.096	.004	.001	3	5
PANCREAS	LOXL2 →	+2.042	+1.213	.002	<.001	3	4
PANCREAS	ZNF461 →	+0.940	+1.188	.005	.001	3	4
LIVER	PSME3IP1 →	+0.418	+2.037	.002	<.001	3	4
LARGE_INTESTINE	WFDC3 →	+1.321	+1.256	.002	.001	3	4
LARGE_INTESTINE	CATSPER1 →	+1.240	+1.025	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNTTIP1 by Cytolysis activity — LARGE_INTESTINE

Explore this box plot interactively →