One-carbon compound transport

Across TCGA patient cohorts, RNA activity of the One-carbon compound transport pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC4A4, LDHAL6EP, and CLU, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, One-carbon compound transport activity versus SLC4A4 in PDAC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SLC4A4 →	+1.483	+1.350	<.001	<.001	3	8
PDAC	LDHAL6EP →	+1.241	+1.317	<.001	<.001	3	5
PDAC	CLU →	+0.978	+1.479	<.001	<.001	3	5
BRCA	STEAP4 →	+1.180	+0.607	.004	.008	3	4
LUAD	TC2N →	+0.781	+1.178	<.001	<.001	3	4
PDAC	ESRRG →	+0.833	+1.556	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019755 vs SLC4A4 — PDAC

Explore this scatter interactively →