One-carbon compound transport

Across TCGA cell cohorts, RNA activity of the One-carbon compound transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAMK2G, PPP1R3F, and TYR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CAMK2G grouped by One-carbon compound transport-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CAMK2G →	+0.660	+0.806	.009	.005	3	4
BLOOD_Leukemia	PPP1R3F →	+0.624	+0.850	.006	.009	2	5
BLOOD_Myeloma	TYR →	+0.043	+0.814	.002	.008	3	3
BREAST	PAQR5 →	+0.799	+0.598	.004	.004	3	3
SKIN	EPHA4 →	+1.466	+0.805	.001	.008	2	4
OESOPHAGUS	PMEPA1 →	+2.877	+1.153	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CAMK2G by One-carbon compound transport activity — BLOOD_Leukemia

Explore this box plot interactively →