Polyol metabolic process

Across TCGA patient cohorts, RNA activity of the Polyol metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FGF1, NUP160, and ARHGAP26, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polyol metabolic process activity versus FGF1 in OV (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FGF1 →	+0.824	+0.028	<.001	.002	3	6
BRCA	NUP160 →	-0.225	-0.020	.007	.008	3	6
GBM	ARHGAP26 →	+0.289	+0.044	.001	<.001	3	6
OV	STK10_S514 →	+0.998	+0.023	<.001	.004	3	5
OV	ZNF318_S709 →	-0.613	-0.034	.008	<.001	3	5
OV	CAPN2 →	+0.390	+0.023	.008	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019751 vs FGF1 — OV

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