Polyol metabolic process

Across TCGA cell cohorts, RNA activity of the Polyol metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL19, CC2D1B, and DGKD, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPL19 grouped by Polyol metabolic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RPL19 →	+0.730	+1.426	<.001	<.001	3	3
BLOOD_Leukemia	CC2D1B →	-0.562	-0.933	.007	.006	3	3
BLOOD_Leukemia	DGKD →	+1.427	+1.042	<.001	.001	3	3
UPPER_AERODIGESTIVE_TRACT	ANKH →	+1.271	+0.894	<.001	.007	3	3
BLOOD_Lymphoma	CNTN2 →	+0.083	+1.208	<.001	.005	2	4
CNS	CIAO1 →	-0.310	-0.714	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPL19 by Polyol metabolic process activity — SOFT_TISSUE

Explore this box plot interactively →