Polyol metabolic process

Across TCGA cell cohorts, RNA activity of the Polyol metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OXA1L, ABHD11, and STRN3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polyol metabolic process activity versus OXA1L in LUNG_NSCLC_LUAD (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OXA1L →	+0.519	+0.141	<.001	.002	3	6
STOMACH	ABHD11 →	+1.258	+0.231	.002	.002	3	5
KIDNEY	STRN3 →	+0.972	+0.272	.006	.004	3	5
STOMACH	HSF2BP →	-0.767	-0.229	.002	.002	3	5
LUNG_SCLC	VKORC1L1 →	+0.444	+0.227	.002	.008	3	4
BLOOD_Leukemia	NUDT7 →	-1.338	-0.172	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019751 vs OXA1L — LUNG_NSCLC_LUAD

Explore this scatter interactively →