Antifungal humoral response

Across TCGA patient cohorts, RNA activity of the Antifungal humoral response pathway is significantly associated with the RNA expression of multiple genes, with the ACC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RARRES2, ZWILCH, and PTPN11, each associated with the pathway in up to 26 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antifungal humoral response activity versus RARRES2 in ACC (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	RARRES2 →	+3.792	+0.113	<.001	<.001	3	26
ACC	ZWILCH →	-0.841	-0.095	.005	.004	1	24
UCS	PTPN11 →	-0.771	-0.112	.003	.004	2	23
UCS	HMGXB4 →	-0.763	-0.117	.001	.003	3	21
UCS	SMC3 →	-0.975	-0.130	.002	.002	2	22
READ	KRR1 →	-0.603	-0.042	<.001	<.001	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019732 vs RARRES2 — ACC

Explore this scatter interactively →