Antifungal humoral response

Across TCGA patient cohorts, RNA activity of the Antifungal humoral response pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC1, CTNNBL1, and YTHDC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antifungal humoral response activity versus RFC1 in BRCA (Pearson r = -0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RFC1 →	-0.307	-0.082	<.001	.001	3	5
PDAC	CTNNBL1 →	-0.142	-0.087	.002	.001	3	5
GBM	YTHDC1 →	-0.303	-0.153	<.001	.001	3	5
GBM	RUFY1 →	+0.249	+0.151	<.001	.001	3	4
BRCA	UCHL3_S130 →	+0.385	+0.082	.001	<.001	3	4
OV	CPN2 →	-0.404	-0.068	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019732 vs RFC1 — BRCA

Explore this scatter interactively →