Antifungal humoral response

Across TCGA patient cohorts, RNA activity of the Antifungal humoral response pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXCL5, CXCL1, and CLEC4E, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antifungal humoral response activity versus CXCL5 in PDAC (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CXCL5 →	+1.961	+0.207	.002	<.001	3	5
UCEC	CXCL1 →	+1.398	+0.341	.003	.004	3	5
UCEC	CLEC4E →	+1.128	+0.507	<.001	<.001	3	5
HNSC	CXCL8 →	+1.380	+0.155	<.001	<.001	3	5
LSCC	MEFV →	+0.686	+0.155	<.001	<.001	3	5
HNSC	CSF3R →	+0.854	+0.131	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019732 vs CXCL5 — PDAC

Explore this scatter interactively →