Antifungal humoral response

Across TCGA cell cohorts, RNA activity of the Antifungal humoral response pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIB2, KIF18A, and SLC9A3R1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antifungal humoral response activity versus TRIB2 in OESOPHAGUS (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TRIB2 →	-1.774	-1.360	.009	<.001	3	3
BREAST	KIF18A →	+0.952	+0.910	.005	.003	3	3
LUNG_NSCLC_LUAD	SLC9A3R1 →	-1.369	-1.082	<.001	<.001	3	3
LUNG_NSCLC_LUAD	ASNSD1 →	+0.878	+1.213	<.001	<.001	3	3
OVARY	TNKS →	+0.956	+1.768	.007	<.001	3	3
CNS	NKAIN3 →	-1.457	-1.272	.006	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019732 vs TRIB2 — OESOPHAGUS

Explore this scatter interactively →