Antibacterial humoral response

Across TCGA patient cohorts, RNA activity of the Antibacterial humoral response pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEC11C, CD38, and MZB1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antibacterial humoral response activity versus SEC11C in HNSC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SEC11C →	+1.058	+0.141	<.001	<.001	3	9
HNSC	CD38 →	+1.013	+0.138	<.001	<.001	3	9
OV	MZB1 →	+1.498	+0.117	<.001	<.001	3	9
OV	SAMHD1 →	+0.504	+0.083	<.001	<.001	3	8
OV	SDF2L1 →	+0.446	+0.107	<.001	<.001	3	8
LSCC	BIN2_S458 →	+0.751	+0.095	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019731 vs SEC11C — HNSC

Explore this scatter interactively →