Antibacterial humoral response

Across TCGA patient cohorts, RNA activity of the Antibacterial humoral response pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEACAM3, CXCR2, and VNN3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Antibacterial humoral response activity versus CEACAM3 in COAD (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CEACAM3 →	+0.634	+0.189	.001	.007	3	7
LSCC	CXCR2 →	+1.037	+0.235	<.001	<.001	3	7
HNSC	VNN3 →	+0.846	+0.285	<.001	<.001	3	7
GBM	LIF →	+1.908	+0.287	<.001	<.001	3	7
LSCC	ADGRG3 →	+0.773	+0.206	<.001	<.001	3	7
GBM	LILRA5 →	+0.828	+0.238	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019731 vs CEACAM3 — COAD

Explore this scatter interactively →