B cell mediated immunity

Across TCGA patient cohorts, RNA activity of the B cell mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPHB2, TTYH3, and PLBD2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, B cell mediated immunity activity versus EPHB2 in BRCA (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EPHB2 →	+0.663	+0.215	.009	.006	3	5
PDAC	TTYH3 →	+0.371	+0.156	.007	.009	3	5
PDAC	PLBD2 →	+0.315	+0.152	.002	.002	3	5
CCRCC	ITGB2 →	+0.746	+0.207	<.001	<.001	3	5
CCRCC	OSCAR →	+0.717	+0.211	<.001	.002	3	5
UCEC	TMEM168 →	-0.814	-0.282	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019724 vs EPHB2 — BRCA

Explore this scatter interactively →