B cell mediated immunity

Across TCGA cell cohorts, RNA activity of the B cell mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZC3H11B, HSPH1, and RPL5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZC3H11B grouped by B cell mediated immunity-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ZC3H11B →	+0.407	+0.214	.001	<.001	3	3
LUNG_SCLC	HSPH1 →	-1.205	-0.244	.003	<.001	3	3
LUNG_SCLC	RPL5 →	+0.678	+0.211	<.001	<.001	3	3
LUNG_SCLC	BTF3 →	+0.604	+0.179	.006	.003	3	3
LUNG_SCLC	RPL14 →	+0.851	+0.261	.004	<.001	3	3
KIDNEY	RMDN2 →	-0.597	-1.086	.008	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZC3H11B by B cell mediated immunity activity — BONE

Explore this box plot interactively →