B cell mediated immunity

Across TCGA cell cohorts, RNA activity of the B cell mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAL, SOCS5, and FGF2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, B cell mediated immunity activity versus ADAL in STOMACH (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ADAL →	+1.058	+0.214	.007	.002	3	5
OESOPHAGUS	SOCS5 →	+0.641	+0.191	.004	.003	3	5
BLOOD_Myeloma	FGF2 →	+1.940	+0.272	<.001	.002	3	5
LIVER	DPYSL3 →	+4.050	+0.228	.008	.008	3	4
LIVER	RNF169 →	+0.895	+0.252	.003	<.001	3	4
LIVER	TMEM126A →	+0.722	+0.252	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019724 vs ADAL — STOMACH

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