Calcium-mediated signaling

Across TCGA patient cohorts, RNA activity of the Calcium-mediated signaling pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP1A2, NEK2, and URB2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcium-mediated signaling activity versus ATP1A2 in HNSC (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ATP1A2 →	+2.777	+0.461	.002	.001	3	4
BRCA	NEK2 →	-1.015	-0.319	<.001	<.001	3	4
BRCA	URB2 →	-0.311	-0.200	.004	.005	3	4
BRCA	JAM2 →	+0.652	+0.217	<.001	.002	3	4
OV	ADH1B →	+1.388	+0.123	.003	.005	3	4
PDAC	MYH1 →	+0.371	+0.281	.008	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019722 vs ATP1A2 — HNSC

Explore this scatter interactively →