Calcium-mediated signaling

Across TCGA cell cohorts, RNA activity of the Calcium-mediated signaling pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDYN, ERCC3, and ARFGAP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PDYN grouped by Calcium-mediated signaling-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PDYN →	-0.220	-0.160	<.001	<.001	3	4
BLOOD_Leukemia	ERCC3 →	+0.190	+0.279	<.001	<.001	3	4
KIDNEY	ARFGAP1 →	-0.175	-0.747	.006	.008	2	5
BLOOD_Leukemia	CD226 →	+0.218	+0.326	.001	.006	3	3
BLOOD_Leukemia	RHOH →	+0.146	+0.325	<.001	.006	3	3
SKIN	CCDC169-SOHLH2 →	-0.133	-0.774	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PDYN by Calcium-mediated signaling activity — LARGE_INTESTINE

Explore this box plot interactively →