Calcium-mediated signaling

Across TCGA cell cohorts, RNA activity of the Calcium-mediated signaling pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XRCC3, IVD, and TESC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, XRCC3 grouped by Calcium-mediated signaling-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	XRCC3 →	+0.867	+0.124	<.001	.004	3	3
BLOOD_Lymphoma	IVD →	-1.447	-0.311	.005	<.001	3	3
LARGE_INTESTINE	TESC →	-2.360	-0.287	<.001	.008	3	3
SKIN	B4GALT2 →	+0.450	+1.076	.003	<.001	3	3
SKIN	WDR53 →	+0.414	+0.669	.001	.009	3	3
BLOOD_Myeloma	ELMOD3 →	-0.625	-1.020	.008	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

XRCC3 by Calcium-mediated signaling activity — LUNG_SCLC

Explore this box plot interactively →