Calcium-mediated signaling

Across TCGA cell cohorts, RNA activity of the Calcium-mediated signaling pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HAUS6, FANCL, and CASP7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcium-mediated signaling activity versus HAUS6 in LIVER (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	HAUS6 →	-0.830	-0.202	.001	.004	3	5
LIVER	FANCL →	-1.184	-0.202	.003	.004	3	4
LUNG_NSCLC_LUAD	CASP7 →	+0.754	+0.381	<.001	.005	3	4
LUNG_SCLC	TNFSF10 →	+1.124	+0.694	.002	.001	3	4
STOMACH	FSD1 →	-2.911	-1.160	.005	.009	3	3
STOMACH	CTSC →	+2.418	+1.218	.009	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0019722 vs HAUS6 — LIVER

Explore this scatter interactively →